DPP shapes up wing cells
نویسندگان
چکیده
منابع مشابه
DPP shapes up wing cells
DPP shapes up wing cel ls PP is not a savior for fly epithelial cells, according to new reports from Matthew Gibson and Norbert Perrimon (Harvard Medical School, Boston, MA) and from Jie Shen and Christian Dahmann (Max Planck Institute, Dresden, Germany). Once thought to be a survival factor in the wing imaginal disc, the DPP morphogen is now shown to regulate cell architecture. Previous experi...
متن کاملTransducing the Dpp Morphogen Gradient in the Wing of Drosophila Regulation of Dpp Targets by brinker
Dpp, a TGFbeta, organizes pattern in the Drosophila wing by acting as a graded morphogen, activating different targets above distinct threshold concentrations. Like other TGFbetas, Dpp appears to induce transcription directly via activation of a SMAD, Mad. However, here we demonstrate that Dpp can also control gene expression indirectly by downregulating the expression of the brinker gene, whic...
متن کاملDpp receptor levels contribute to shaping the Dpp morphogen gradient in the Drosophila wing imaginal disc.
Axis formation in the Drosophila wing depends on the localized expression of the secreted signaling molecule Decapentaplegic (Dpp). Dpp acts directly at a distance to specify discrete spatial domains, suggesting that it functions as a morphogen. Expression levels of the Dpp receptor thick veins (tkv) are not uniform along the anterior-posterior axis of the wing imaginal disc. Receptor levels ar...
متن کاملDpp Gradient Formation in the Drosophila Wing Imaginal Disc
The secreted signaling protein Dpp acts as a morphogen to pattern the anterior-posterior axis of the Drosophila wing. Dpp activity is required in all cells of the developing wing imaginal disc, but the ligand gradient that supports this activity has not been characterized. Here we make use of a biologically active form of Dpp tagged with GFP to examine the ligand gradient. Dpp-GFP forms an unst...
متن کاملExtrusion and death of DPP/BMP-compromised epithelial cells in the developing Drosophila wing.
During animal development, epithelial cell fates are specified according to spatial position by extracellular signaling pathways. Among these, the transforming growth factor beta/bone morphogenetic protein (TGF-beta/BMP) pathways are evolutionarily conserved and play crucial roles in the development and homeostasis of a wide range of multicellular tissues. Here we show that in the developing Dr...
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ژورنال
عنوان ژورنال: Journal of Cell Biology
سال: 2005
ISSN: 1540-8140,0021-9525
DOI: 10.1083/jcb1691rr5